ABSTRACT

It was thougt that addition of calcium dobesilate to therapy would have a beneficial influence on improving the symptoms in the patients who e receive medication for acute deep venous thrombosis (DVT).

A total of 88 patients with acute deep venous thrombosis (DVT) were evaluated between October 2010-2011. Patients were divided into two groups. In both groups, the patients were anticoagulated with one dose enoxaparine daily for ten days and then warfarin during 6 months. A total of 1.5 g/day calcium dobesilate was added to therapy which the patients were given in group A. The patients who were in group B were followed with only anticoagulant treatment as a control group. All patients in both groups were evaluated with physical examination and venous duplex ultrasonography (VDU) in the second week, 1, 2 and 6 months after diagnosis of disease.

Subacute findings in VDU were seen in 24 patients in the second week, 16 in first month, 4 in the second month in group A, 28 them in the second week, 8 in the first month, 8 in the second month control in group B. Leg edema returned to normal limits in the 24 patients in the second week, 8 of them in the first month, 8 of them in the second month, 2 of them in the sixth month in group A, 25 in thesecond week, 8 in the first month, 6 in the second month, 5 in the sixth month in group B. It was seen that leg pain was reduced in 36patients in the second week, 8 in the first month in group A, 30 in the second week, 14 in the first month in group B.

Added therapy with calcium dobesilate contributes to improving symptoms in patients who have acute DVT.

Keywords: Acute deep venous thrombosis (DVT), calcium dobesilate, enoxaparine