Serum 25-Hydroxy Vitamin D Levels in Patients with Acute Hepatitis (Ischemic, Toxic, and Viral): Association With Clinical Progression and Mortality
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Original Article
P: 23-27
March 2017

Serum 25-Hydroxy Vitamin D Levels in Patients with Acute Hepatitis (Ischemic, Toxic, and Viral): Association With Clinical Progression and Mortality

İstanbul Med J 2017;18(1):23-27
1. Department of Internal Medicine, Kaçkar State Hospital, Rize, Türkiye
2. Department of Internal Medicine, Okmeydanı Training and Research Hospital, İstanbul, Türkiye
3. Department of Internal Medicine, Görele State Hospital, Giresun, Türkiye
4. Department of Internal Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Türkiye
No information available.
No information available
Received Date: 16.05.2016
Accepted Date: 19.10.2016
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ABSTRACT

Objective:

Vitamin D is a key regulator of calcium homeostasis and has anti-inflammatory and immunomodulatory effects. Active vitamin D has a direct effect on T cells and antigen-presenting cells. It also suppresses the differentiation of B cells to plasma cells and inhibits immunoglobulin production. Vitamin D supplementation is associated with a favorable outcome in chronic inflammatory diseases. In this study, we aimed to determine serum vitamin D levels in patients with acute toxic, ischemic, or viral hepatitis and whether the levels had an effect on clinical progression or mortality in patients with acute hepatitis.

Methods:

Forty-eight patients (26 men and 22 women) and 35 controls (16 men and 19 women) aged >18 years who were diagnosed as having acute hepatitis and hospitalized in the Internal Medicine Department were enrolled. To determine serum 25-hydroxy (OH) vitamin D levels, two fasting blood samples, first in the initial 24–48 h following hospitalization and second on the day of discharge, were obtained from the participants. The SPSS Statistics v21.0 software was used for the quantitative evaluation of data.

Results:

Serum vitamin D levels were significantly lower in the patient group (10.0±8.7) than in the control group (31.5±12.2), but no significant difference was detected in serum vitamin D levels among the patients. Serum vitamin D levels, except in patients with viral hepatitis, were low at discharge. Serum vitamin D levels were lower than the cutoff values in two patients with early mortality.

Conclusion:

We demonstrated that serum vitamin D levels had no effect on clinical progression of acute hepatitis. Other prospective studies with large sample sizes are required to determine whether serum vitamin D levels can be used to predict clinical progression or mortality.