ABSTRACT

It's observed that the urine albumin exeretian increases in patients with coronary heart diseases like diabetic patients. In our study which is performed between April-July 1996, there were 3 groups of 46 patients; 19 patients diagnosed as acute myocandial infaretion (AMI) at admission (Group 1), 13 patients diagnosed as AM! thereafter (Group II), 14 patients that were suspected but didn't develop AMI (Group III) and 20 healthy subjects as the control group (Group N). Albumin/Creatinin (A/C) ratio in the first urine of all the patients were analysed. Microalbuminuria levels of all the patient groups were determined at the admission and for the following three days. ECG; serum glucose, urea, creatinine, CK, CK-MB, AS1; ALT, LDH levels were also determined. Urinary al bumin exeretian levels were detected over 30mgr 1 L in 58% of Group I, 31% of Group II and 14% of group III patients. Albuminuria exceeded 30 mg 1 L in the 77% of group II patients in the same manner with the peak values in AST levels in the first 2 days. Albuminuria levels decreased in patients with AMI in the following days. Patients treated with STK+Heparin or with only heparin which are called group la and group Ib were compered w ith first u ri ne A 1 C ratios, but no statistical significance was detected. lncreased renal permeability has been blamed as the cause of increased urinary albumin excretion. Microalbuminuria which is parellel with high AST values at AM! can be usedas a predictor of myocardial necrosis.