Effects of Boric Acid on Ehrlich Ascites Tumor
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Original Investigation
P: 251-254
September 2018

Effects of Boric Acid on Ehrlich Ascites Tumor

İstanbul Med J 2018;19(3):251-254
1. Sağlık Bilimleri Üniversitesi İstanbul Eğitim ve Araştırma Hastanesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye
2. Bursa Yüksek İhtisas Eğitim Ve Araştırma Hastanesi, Genel Cerrahi Anabilim Dalı, Bursa, Türkiye
3. Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Genetik Bilim ve Biyoteknoloji Araştırma Merkezi, İstanbul, Türkiye
4. Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye
No information available.
No information available
Received Date: 25.10.2017
Accepted Date: 22.12.2017
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ABSTRACT

Conclusion:

The intraperitoneal administration of boric acid in the Ehrlich tumor model showed no effect on cancer development.

Results:

None of the rats were sacrificed, and the weight increase time was considered as the starting point of the tumor. There was no significant difference between all groups with respect to tumor initiation times and survival times. Histopathological examinations revealed no significant differences between tumor foci and tumor diameters.

Methods:

In total, 21 female BALB/c mice (mean weight, 27.5 g; mean age, 4 months) were divided into three equal groups. In each group, 1000 Ehrlich tumor cells were implanted intraperitoneally. The first group was intraperitoneally administered 1 mg/day NaH3BO3 solution before Ehrlich tumor implantation. The second group was intraperitoneally administered 1 mg/day NaH3BO3 solution simultaneously with Ehrlich tumor implantation. The third group was intraperitoneally administered 1 ml/day 0.9% NaCl simultaneously with Ehrlich tumor implantation. All administrations continued until the subjects died.

Introduction:

Cancer is one of the most important healthcare problems in the world. Boric acid has cytotoxic activity, but there is insufficient data on its effectiveness for cancer development. In this study, we investigated the effect of boric acid on cancer development was investigated in the mouse model for Ehrlich tumor.

Keywords:
Ehrlich tumor, boric acid, animal study, peritoneum