ABSTRACT

In this study, outcome of antagonist and agonist protocols in normo-responsive women were compared.

Two hundred and forty patients with normal ovarian reserve were included in the study. Patients were treated with GnRH antagonists and GnRh agonists, and pregnancy outcomes were compared between the two groups.

Forty seven patients (46.1%) who were treated with the long GnRh protocol, and 57 patients (41.6%) who were treated with the antagonis protocol achieved pregnancy. There was not a statistically significant difference in the pregnancy rates of the two groups (p=0.49, p>0.05) Likewise, no significant difference was found regarding infertility duration (p=0.93), embryo transfer day (p=0.64), total number of oocytes pickedup (p=0.57).

In normo-responsive women, antagonist protocol is found to be as effective as the long agonist protocol. Antagonist use as a first line treatment in normo-responsive women should be further investigated.

Keywords: GnRH agonist, GnRH antagonist, assisted reproductive