Association of Benign Breast Disorders with Hypothyroidism

İstanbul Med J 2018;19(3):246-250

DOI: 10.5152/imj.2018.44452

1. Department of Surgery, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

2. Vali-e-Asr Reproduction Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

3. Breast Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran

4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

5. Endocrine Research Center, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran

6. Department of Pathology, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

7. Research Development Center, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran

No information available.

No information available

Received Date: 31.05.2017

Accepted Date: 20.07.2018

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ABSTRACT

Conclusion:

The present study demonstrates no significant association between hypothyroidism and BBD.

Results:

Hypothyroidism was insignificantly more frequent in the case (5.8%) than in the control group (5.3%), as well as in cases of fibrocystic changes (7.9%) in comparison with mastalgia (1.4%) and nipple discharge (2.6%) in the BBD subgroups (p=0.85 and 0.09, respectively). On contrary, Hashimoto’s disease was slightly more frequent in controls, but the difference was not significant (p=0.70).

Methods:

In this case-control study, 226 women with BBD without a history of thyroid disorders were recruited consecutively as the case group. Controls included 206 healthy women without breast disease. Blood samples were taken, and the levels of free thyroxin, tri-iodothyronine, thyroid stimulating hormone, prolactin, and anti-thyroid peroxidase antibody were measured.

Introduction:

More than half of women complaining of breast symptoms are affected by benign breast disorders (BBD). Thyroid dysfunction has been implicated as the etiology. Therefore, we conducted a study to assess the association between BBD and hypothyroidism.