Abstract
The determination of Carbohydrate Deficient Transferrin (CDT) for diagnosing alcoholism and fallawing treatment has gained importance.In our study, we determined the levels of total transferrin (TF), CDT, Aspartate Transaminase (AST), Alanin Transaminase (ALT), Gammaglutamyl-transferase (GGT), Lactate Dehydrogenase (LDH), Allcaline Phosphatase (ALP), Mean Corpuscular Volume (MCV) and % CDT in 22-alcohol-dependent subjects, 22 patients having non-alcoholic fatty liver and in 22 healthy control subjects. In aleohal dependent subjects, patients having non-alcoholic fatty liver and in control subjects, serum total TF (mg 1 L), serum CDT (mg 1 L) and % CDT levels were found as 7124±1668; 9630±3556, 8420±3538; 16.0±3.1, 6.0±1.8, 6.9±2.3; 5.3±1.2, O. 70±0.08, 1.1±0.5 respectively. The levels of serum total TF were found significantly higher in the patients having non-alcoholic fatty liver comparing to those of other groups (p<0.05). Serum CTD and % CDT values were significantly higher in alcohol-dependent group than those of other group than those of other groups (p<O.Ol). The diagnostic sensitivity and specificity of% CDT were 78% and 100% respectively. Although we determined significantly higher CDT levels of alcohol dependent subjects comparing to those of patients having non-alcoholic fatty liver and control subjects, CDT % levels seems to be a more objective tool since TF which is a negative acute phase reactant may have different values in various elinical situations.
Keywords: Karbonhidratı eksik transferrin, Alkolizm, Karaciğer Yağlanması
