Objective:

The aim of this study is to determine the importance of factors, such as mean platelet volume (MPV), fibrinogen, HbA1c, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, and fasting glucose, on cardiovascular complication processes for type 2 diabetes mellitus patients without coronary artery disease (CAD) and also to compare the relationship between these risk factors.

Methods:

For this study, data of 182 patients who with coronary hard disease and diabetes mellitus were retrospectively analyzed. The patients were followed up at the Outpatient Clinic of Diabetes of Istanbul Education and Research Hospital between 01.01.2009-31.12.201.The mean age of patients were 63.07±11.24 (40-90) years. 115 (63.2%) patients were male and 67 (36.8%) patients were female. The patients were divided into three groups: group 1: patients who had CAD but no DM (n=59), group 2: patients who had CAD and DM (n=60), and group 3: patients who had DM but no CAD (n=62).

Results:

201 The mean age of patients was 63.07±11.24 years; 115 patients were male and 67 were female. The patients were divided into three groups: group 1: patients who had CAD but no DM (n=59), group 2: patients who had CAD and Diabetes Mellitus (DM) (n=60), and group 3: patients who had DM but no CAD (n=62). The mean age of patients in each group was as follows: 64±13, 62±9, and 57±11 years. According of post hoc analyses, the fibrinogen and MPV values of group 3 were lower than group 1 and group 2. There was a statistical difference between the groups in terms of mean values of total cholesterol, LDL-cholesterol, HbA1c, and the median values of fasting glucose and triglyceride. There was no difference between the 3 groups in terms of mean values of HDL-cholesterol.

Conclusion:

In conclusion, MPV and fibrinogen values may be independent risk factors of cardiovascular complications for type 2 DM patients and may be suggested as useful markers to follow up patients for progression to coronary artery disease.

Keywords: Diabetes mellitus, coronary artery disease, mean platelet volume, fibrinogen