Objective:

It was thougt that addition of calcium dobesilate to therapy would have a beneficial influence on improving the symptoms in the patients who e receive medication for acute deep venous thrombosis (DVT).

Methods:

A total of 88 patients with acute deep venous thrombosis (DVT) were evaluated between October 2010-2011. Patients were divided into two groups. In both groups, the patients were anticoagulated with one dose enoxaparine daily for ten days and then warfarin during 6 months. A total of 1.5 g/day calcium dobesilate was added to therapy which the patients were given in group A. The patients who were in group B were followed with only anticoagulant treatment as a control group. All patients in both groups were evaluated with physical examination and venous duplex ultrasonography (VDU) in the second week, 1, 2 and 6 months after diagnosis of disease.

Results:

Subacute findings in VDU were seen in 24 patients in the second week, 16 in first month, 4 in the second month in group A, 28 them in the second week, 8 in the first month, 8 in the second month control in group B. Leg edema returned to normal limits in the 24 patients in the second week, 8 of them in the first month, 8 of them in the second month, 2 of them in the sixth month in group A, 25 in thesecond week, 8 in the first month, 6 in the second month, 5 in the sixth month in group B. It was seen that leg pain was reduced in 36patients in the second week, 8 in the first month in group A, 30 in the second week, 14 in the first month in group B.

Conclusion:

Added therapy with calcium dobesilate contributes to improving symptoms in patients who have acute DVT.

Keywords: Acute deep venous thrombosis (DVT), calcium dobesilate, enoxaparine