OBJECTIVE:

Heart failure is a complex clinical syndrome in which an abnormality of cardiac structure or function is responsible for the inability of the heart to eject enough amount of blood required by the body tissues. ECHO (Eehocardiography) is the most reliable but costly method in the diagnosis of heart failure. In this study, the significance and correlation between echocardiographic findings and the serum levels of both proBNP and hs-CRP levels are evaluated.

METHODS:

A total ffifty patients (22 women, 28 men) with the diagnosis of heart failure and disease and 40 healthy individuals, as control subjects (16 women, 24 men) were included to our study. The serum levels of pro-BNP and hs-CRP were determined in the group of heart failure patients with the ejection fraction (EF) values under 50%, and normal individuals (control subjects).

RESULTS:

Mean ± SD age value of included groups to study was 60.76 ± 17.04 (n=90). The correlation values between serum levels of both pro-BNP and hs-CRP levels with EFs respectively were r=0,360 (p=0,0001); r=-0,392 (p=0,0001). Mean ± SD values of the patients who have EF under 50% values and the patients who have EF values above 50%, were respectively 9038,04 ± 10665 and 1914,47 ± 7828,76 (p=0,001) for pro-BNP and 3,20 ± 3,63 ve 0,54 ± 0,70 (p=0,001) for hs-CRP.

CONCLUSION:

In this study our results show that both serum hs-CRP and pro-BNP levels were higher in patients with heart fai/ure and prognostie value of high serum hs-CRP levels were independent from serum pro-BNP levels in ıhese patients.

Keywords: Brain natriuretic peptit, Echocardiography, Hear failure