Here we present the case of a patient who was diagnosed with non-familial angioedema (AE) and who had a high risk of connective tissue disease. The patient had recurrent AE and arthritis attacks. C1 inhibitor level was found to be borderline low, and the antinuclear antibody (ANA) level was significantly high. The patient is being followed up with an antihistaminic treatment. The association of AE with systemic lupus erythematosus (SLE) is a rare condition. The possibility of collagen tissue disease, especially SLE not reflected in the clinic in our case, is strong.
Keywords: Antinuclear antibody, angioedema, C1 inhibitor deficiency